Wild West C.O.W.-Boys of Moo Mesa is a 1992 coin-operated arcade game based on the animated series of the same name. The game was released by Konami and is a side-scrolling "run 'n gun" action game similar to the publisher's previous wild west-themed game Sunset Riders. Moo Mesa creator Ryan Brown worked closely with Konami on the game's development.
The game's controls consist of an eight-way joystick and two buttons for shooting and jumping. Pressing both buttons simultaneously will cause the player character to perform a stampede attack, do a spinning jump, or use any equipped item like dynamite sticks and tomahawk blades. The player can uncover a variety of power-up items by shooting flying chickens, which includes a rapid-fire Machine Gun and a Power-Up for wider bullets. Unlike Sunset Riders, the player has a three-unit life gauge that allows the player to take three hits before losing a life.